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12 pages, 2130 KiB  
Article
Variability in Pine Pitch Canker Susceptibility among Scots Pine (Pinus sylvestris) Provenances in Eastern Europe
by Kateryna Davydenko, Natalia ?ukaszewska-Skrzypniak, Katarzyna Sadowska, Justyna Anna Nowakowska, Kristina Raitelaityt?, Svetlana Markovskaja, Daiva Burokien?, Olena Shcherbak, Jorge Martín-García, Julio Javier Diez Casero, Tom Hsiang and Tomasz Oszako
Forests 2024, 15(4), 613; https://doi.org/10.3390/f15040613 (registering DOI) - 28 Mar 2024
Abstract
Pine pitch canker, caused by the ascomycete Fusarium circinatum, poses a substantial threat to pine trees and Douglas firs (Pseudotsuga menziesii), and has been identified as a pervasive issue in forests and nurseries worldwide, particularly in regions where susceptible conifers [...] Read more.
Pine pitch canker, caused by the ascomycete Fusarium circinatum, poses a substantial threat to pine trees and Douglas firs (Pseudotsuga menziesii), and has been identified as a pervasive issue in forests and nurseries worldwide, particularly in regions where susceptible conifers are cultivated. Given its prevalence in the Iberian Peninsula, assessments of the susceptibility of diverse European provenances of Scots pine (Pinus sylvestris)—specifically those from Poland, Lithuania, and Ukraine—have been conducted. Preliminary evaluations of Polish provenances have raised concerns about the potential threat to Scots pine stands in Poland posed by pitch canker. Under controlled conditions, we examined the impact of F. circinatum inoculation on the survival of seeds and seedlings from ten provenances of Scots pine. In response, the initial assessment of F. circinatum pathogenicity was undertaken in a controlled greenhouse environment. This evaluation uncovered a heightened susceptibility of pine seedlings to pitch canker among the tested provenances. Notably, one Lithuanian provenance demonstrated superior resistance to pitch canker, while two Polish provenances exhibited a higher prevalence of symptomless seedlings. These findings underscore the need for further exploration and identification of resilient individuals within these provenances, offering valuable insights for developing strategies to mitigate the impact of pitch canker on Scots pine in Europe. Full article
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18 pages, 1212 KiB  
Article
A UWB-Ego-Motion Particle Filter for Indoor Pose Estimation of a Ground Robot Using a Moving Horizon Hypothesis
by Yuri Durodié, Thomas Decoster, Ben Van Herbruggen, Jono Vanhie-Van Gerwen, Eli De Poorter, Adrian Munteanu and Bram Vanderborght
Sensors 2024, 24(7), 2164; https://doi.org/10.3390/s24072164 (registering DOI) - 28 Mar 2024
Abstract
Ultra-wideband (UWB) has gained increasing interest for providing real-time positioning to robots in GPS-denied environments. For a robot to act on this information, it also requires its heading. This is, however, not provided by UWB. To overcome this, either multiple tags are used [...] Read more.
Ultra-wideband (UWB) has gained increasing interest for providing real-time positioning to robots in GPS-denied environments. For a robot to act on this information, it also requires its heading. This is, however, not provided by UWB. To overcome this, either multiple tags are used to create a local reference frame connected to the robot or a single tag is combined with ego-motion estimation from odometry or Inertial Measurement Unit (IMU) measurements. Both odometry and the IMU suffer from drift, and it is common to use a magnetometer to correct the drift on the heading; however, magnetometers tend to become unreliable in typical GPS-denied environments. To overcome this, a lightweight particle filter was designed to run in real time. The particle filter corrects the ego-motion heading and location drift using the UWB measurements over a moving horizon time frame. The algorithm was evaluated offline using data sets collected from a ground robot that contains line-of-sight (LOS) and non-line-of-sight conditions. An RMSE of 13 cm and 0.12 (rad) was achieved with four anchors in the LOS condition. It is also shown that it can be used to provide the robot with real-time position and heading information for the robot to act on it in LOS conditions, and it is shown to be robust in both experimental conditions. Full article
(This article belongs to the Section Sensors and Robotics)
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4 pages, 152 KiB  
Editorial
New Developments in Geometric Function Theory II
by Georgia Irina Oros
Axioms 2024, 13(4), 224; https://doi.org/10.3390/axioms13040224 (registering DOI) - 28 Mar 2024
Abstract
This Special Issue is a sequel to the successful first volume entitled “New Developments in Geometric Function Theory” [...] Full article
(This article belongs to the Special Issue New Developments in Geometric Function Theory II)
21 pages, 3031 KiB  
Article
Effect of Calcium Aluminate and Carbide Slag on Mechanical Property and Hydration Mechanism of Supersulfated Cement
by Guangzheng Qi, Qiang Zhang and Zhengning Sun
Buildings 2024, 14(4), 930; https://doi.org/10.3390/buildings14040930 (registering DOI) - 28 Mar 2024
Abstract
Supersulfated cement (SSC), a low-carbon, energy-efficient, eco-friendly cementitious material, is mainly made from industrial byproducts. However, SSC’s slow early strength development leads to inadequate initial hardening and reduced durability, which restricts its practical application. This study investigated the potential enhancement of SSC by [...] Read more.
Supersulfated cement (SSC), a low-carbon, energy-efficient, eco-friendly cementitious material, is mainly made from industrial byproducts. However, SSC’s slow early strength development leads to inadequate initial hardening and reduced durability, which restricts its practical application. This study investigated the potential enhancement of SSC by incorporating calcium aluminate (CA) and carbide slag (CS) alongside anhydrite as activators to address its slow early strength development. The effects of varying CA and CS proportions on the mechanical property and hydration mechanism of CA-CS-SSC were examined. Results indicate that employing 1% CA and 4% CS as alkaline activators effectively activates slag hydration in the 1CA-4CS-SSC, achieving a compressive strength of 9.7 MPa at 1 day. Despite the limited improvement in early compressive strength of other mixtures with higher CA and lower CS proportions in the CA-CS-SSC system, all mixtures exhibited enhanced compressive strength during long-term hydration. After 90 days, ettringite formation in the CA-CS-SSC system decelerated, whereas anhydrite remained. Concurrently, the formation of C-S-H continued to increase, promoting late compressive strength. The mechanism for enhancing the early compressive strength of the CA-CS-SSC system is attributed to the swift hydration of CA with anhydrite, dissolution of fine slag particles, and reaction with anhydrite under conditions with suitable alkali content to augment the ettringite production. This process also generates a C-S-H and OH-hydrotalcite to fill the void in the skeleton structure formed by ettringite, resulting in a dense microstructure that improves early compressive strength. Full article
(This article belongs to the Special Issue Low-Carbon and Green Materials in Construction—2nd Edition)
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16 pages, 1432 KiB  
Article
A Fundamental Study of Reliable Vehicle-to-Cloud Communication Using Multiple Paths with Redundancy Mitigation
by Rui Teng and Kenya Sato
Appl. Sci. 2024, 14(7), 2841; https://doi.org/10.3390/app14072841 (registering DOI) - 28 Mar 2024
Abstract
The reliability of V2X (vehicle-to-everything) communication is important for safe automated driving. With the advances in wireless communication and multipath transport protocols, a vehicle can employ multiple wireless interfaces and carry out multipath communication. Although there has been extensive research into increasing the [...] Read more.
The reliability of V2X (vehicle-to-everything) communication is important for safe automated driving. With the advances in wireless communication and multipath transport protocols, a vehicle can employ multiple wireless interfaces and carry out multipath communication. Although there has been extensive research into increasing the Quality of Service (QoS) performance, such as throughput and delay in V2X communication, few studies have addressed explicit ways of improving the reliability of vehicle-to-cloud (V2C) communication through multipath-based redundancy. This paper addresses the issue of improving V2C reliably via multipath-based packet duplication, with particular consideration given to redundancy mitigation. We propose a method that employs dynamic adjustment of multipath redundancy to maintain packet-delivery reliability in V2C communication while enabling redundancy mitigation. The evaluation results show that the proposed method allows the vehicle to maintain the desired reliability in terms of successful packet transmission while reducing redundancy caused by packet duplication in a multipath connection. Full article
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14 pages, 3638 KiB  
Article
Oxidative Stress Induced by Cortisol in Human Platelets
by Maria Grazia Signorello, Silvia Ravera and Giuliana Leoncini
Int. J. Mol. Sci. 2024, 25(7), 3776; https://doi.org/10.3390/ijms25073776 (registering DOI) - 28 Mar 2024
Abstract
Hypercortisolism is known to affect platelet function. However, few studies have approached the effect of exogenous cortisol on human platelets, and the results obtained are conflicting and unconvincing. In this study, the effect of exogenous cortisol on several parameters indicative of oxidative status [...] Read more.
Hypercortisolism is known to affect platelet function. However, few studies have approached the effect of exogenous cortisol on human platelets, and the results obtained are conflicting and unconvincing. In this study, the effect of exogenous cortisol on several parameters indicative of oxidative status in human platelets has been analysed. We have found that cortisol stimulates ROS production, superoxide anion formation, and lipid peroxidation, with these parameters being in strict correlation. In addition, cortisol decreases GSH and membrane SH-group content, evidencing that the hormone potentiates oxidative stress, depleting platelet antioxidant defence. The involvement of src, syk, PI3K, and AKT enzymes in oxidative mechanisms induced by cortisol is shown. The main sources of ROS in cells can include uncontrolled increase of NADPH oxidase activity and uncoupled aerobic respiration during oxidative phosphorylation. Both mechanisms seem to be involved in ROS formation induced by cortisol, as the NADPH oxidase 1 inhibitor 2(trifluoromethyl)phenothiazine, and rotenone and antimycin A, complex I and III inhibitor, respectively, significantly reduce oxidative stress. On the contrary, the NADPH oxidase inhibitor gp91ds-tat, malate and NaCN, complex II and IV inhibitor, respectively, have a minor effect. It is likely that, in human platelets, oxidative stress induced by cortisol can be associated with venous and arterial thrombosis, greatly contributing to cardiovascular diseases. Full article
(This article belongs to the Special Issue Drug Discovery and Novel Platelet Signaling in Thrombogenesis)
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6 pages, 1691 KiB  
Interesting Images
The Millepora Zone Is Back: Recent Findings from the Northernmost Region of the Maldives
by Irene Pancrazi, Hassan Ahmed, Giovanni Chimienti and Monica Montefalcone
Diversity 2024, 16(4), 204; https://doi.org/10.3390/d16040204 (registering DOI) - 28 Mar 2024
Abstract
Three species of the tropical hydrocoral genus Millepora were common and abundant in the Maldives before 1998, characterizing extensive shallow reef areas known as ‘Millepora zones’. The 1998 heat wave resulted in mass mortality of all the Millepora species, the characteristic Millepora [...] Read more.
Three species of the tropical hydrocoral genus Millepora were common and abundant in the Maldives before 1998, characterizing extensive shallow reef areas known as ‘Millepora zones’. The 1998 heat wave resulted in mass mortality of all the Millepora species, the characteristic Millepora zones disappeared, and only a few observations of isolated colonies were reported in the years ahead. A recent expedition (January 2024) to the northernmost region of the Maldives (Ihavandhippolhu Atoll) revealed new Millepora zones at 7–13 m depth, suggesting a potential repopulation of a vulnerable genus considered regionally extinct. Full article
(This article belongs to the Collection Interesting Images from the Sea)
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14 pages, 998 KiB  
Article
Associations between Chronic Kidney Disease and Migraine Incidence: Findings from a Korean Longitudinal Big Data Study
by Mi Jung Kwon, Jwa-Kyung Kim, Min-Jeong Kim, Dae Myoung Yoo, Na-Eun Lee, Kyeong Min Han, Nan Young Kim, Ho Suk Kang, Hyo Geun Choi and Eun Soo Kim
J. Pers. Med. 2024, 14(4), 356; https://doi.org/10.3390/jpm14040356 (registering DOI) - 28 Mar 2024
Abstract
While headaches frequently occur in individuals with chronic kidney disease (CKD), there are few statistical evaluations of their connection to migraines in population-based studies. In this nationwide longitudinal follow-up study of Korean health examination data (2002–2019), a total of 15,443 participants with CKD [...] Read more.
While headaches frequently occur in individuals with chronic kidney disease (CKD), there are few statistical evaluations of their connection to migraines in population-based studies. In this nationwide longitudinal follow-up study of Korean health examination data (2002–2019), a total of 15,443 participants with CKD and 61,772 matched controls were enrolled. We applied overlap-weighted Cox proportional hazard regression models to assess hazard ratios, examining the correlation between CKD and the development of migraines. After accounting for various factors, we observed a modest reduction of approximately 11% in the likelihood of migraine occurrence among CKD patients (95% confidence intervals = 0.81–0.97) during the 16-year monitoring period. Subgroup analysis revealed a significant association among specific demographic and health conditions, including individuals aged 70 or older, females, overweight individuals, nonsmokers, and those without hypertension or diabetes. Our research may indicate a potential relationship between CKD and the onset of migraines in Korean adults, suggesting a slight reduction in the probability of the occurrence of migraines among those with CKD. These findings emphasize the need for attentive follow-up and preventive management in individuals without the identified protective factors, particularly in male CKD patients under the age of 70 with hypertension. Full article
(This article belongs to the Special Issue Precision Medicine for Epidemiology and Public Health)
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12 pages, 1595 KiB  
Article
Microbiological Analysis of Manufacturing Processes and Microbial Hazard Assessment of Quality and Safety of Commercial Salted Shrimp (Saeu-jeot)
by Jiyoun Jeong, Heeyoung Lee, Hwan Hee Yu, Jong-Chan Kim, Sunhyun Park and You-Shin Shim
Fishes 2024, 9(4), 118; https://doi.org/10.3390/fishes9040118 (registering DOI) - 28 Mar 2024
Abstract
The objective of this study was to evaluate the microbiological properties of commercially available traditional Korean salted shrimp (Saeu-jeot) and to analyze the effects of saltwater immersion and ultraviolet (UV) irradiation on the reduction of Staphylococcus aureus in Saeu-jeot. A microbiological [...] Read more.
The objective of this study was to evaluate the microbiological properties of commercially available traditional Korean salted shrimp (Saeu-jeot) and to analyze the effects of saltwater immersion and ultraviolet (UV) irradiation on the reduction of Staphylococcus aureus in Saeu-jeot. A microbiological analysis was conducted across 56 commercially available Saeu-jeot samples from the Korean, Chinese, and Vietnamese markets. The microbiological analysis revealed no presence of Escherichia coli, coliforms, or Vibrio parahaemolyticus in any commercial samples. The total viable count and S. aureus were 3.8 ± 0.4 and 0.6 ± 0.3 log CFU/g, respectively. An investigation of the procedures conducted on Saeu-jeot samples at various production stages by Hazard Analysis Critical Control Point (HACCP)-certified companies demonstrated the substantial relevance of the raw material (tiny shrimp) on S. aureus counts. In order to reduce S. aureus in Saeu-jeot, saltwater immersion and UV irradiation treatments were applied, which reduced the S. aureus counts by 1.4 log CFU/g and 0.3 log CFU/g, respectively, and S. aureus’s efficacy was limited to the food’s surface. These results suggest that a co-treatment of saltwater immersion and UV irradiation could be effective in reducing S. aureus. The maintenance of hygienic handling and cleanliness are essential in the modern manufacturing processes of Saeu-jeot. Full article
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15 pages, 3607 KiB  
Article
Nonlinear Growth Dynamics of Neuronal Cells Cultured on Directional Surfaces
by Cristian Staii
Biomimetics 2024, 9(4), 203; https://doi.org/10.3390/biomimetics9040203 (registering DOI) - 28 Mar 2024
Abstract
During the development of the nervous system, neuronal cells extend axons and dendrites that form complex neuronal networks, which are essential for transmitting and processing information. Understanding the physical processes that underlie the formation of neuronal networks is essential for gaining a deeper [...] Read more.
During the development of the nervous system, neuronal cells extend axons and dendrites that form complex neuronal networks, which are essential for transmitting and processing information. Understanding the physical processes that underlie the formation of neuronal networks is essential for gaining a deeper insight into higher-order brain functions such as sensory processing, learning, and memory. In the process of creating networks, axons travel towards other recipient neurons, directed by a combination of internal and external cues that include genetic instructions, biochemical signals, as well as external mechanical and geometrical stimuli. Although there have been significant recent advances, the basic principles governing axonal growth, collective dynamics, and the development of neuronal networks remain poorly understood. In this paper, we present a detailed analysis of nonlinear dynamics for axonal growth on surfaces with periodic geometrical patterns. We show that axonal growth on these surfaces is described by nonlinear Langevin equations with speed-dependent deterministic terms and gaussian stochastic noise. This theoretical model yields a comprehensive description of axonal growth at both intermediate and long time scales (tens of hours after cell plating), and predicts key dynamical parameters, such as speed and angular correlation functions, axonal mean squared lengths, and diffusion (cell motility) coefficients. We use this model to perform simulations of axonal trajectories on the growth surfaces, in turn demonstrating very good agreement between simulated growth and the experimental results. These results provide important insights into the current understanding of the dynamical behavior of neurons, the self-wiring of the nervous system, as well as for designing innovative biomimetic neural network models. Full article
(This article belongs to the Special Issue Biomimetics Models of Cellular Motility)
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19 pages, 272 KiB  
Article
Catholicism, Psychedelics, and Mysticism: Correlations and Displacements
by Mark Slatter
Religions 2024, 15(4), 419; https://doi.org/10.3390/rel15040419 (registering DOI) - 28 Mar 2024
Abstract
This article charts some of the conversations around psychedelics, mysticism, Catholicism, and the Catholic mystics. The first part, “Background and Orientation”, gives context for the current “psychedelic renaissance” and brings the focus to psychedelics and Catholicism. The literature’s frequent comparisons of psychedelic mystical [...] Read more.
This article charts some of the conversations around psychedelics, mysticism, Catholicism, and the Catholic mystics. The first part, “Background and Orientation”, gives context for the current “psychedelic renaissance” and brings the focus to psychedelics and Catholicism. The literature’s frequent comparisons of psychedelic mystical trips with Catholic mysticism raises questions about the legitimacy of religious ways of knowing, the status of the discipline of theology in Western academic cultures, and how Catholicism is often depicted in the psychedelic literature. The first part closes with a survey of the challenges of defining mysticism and some of the patterns perennial to the Catholic mystical experience. In the second part, “Through the Eye of the Methodology Needle”, I look at the problem of methodological displacement, that is, how a researcher comes to conclusions with material that is formally outside of their discipline’s boundaries. This is a challenge for scholars of every stripe when they countenance subject matter that is beyond their expertise—and the lure to still read that material through their known methodology and worldview—but the problem of displacement is conspicuously compounded when the sciences countenance theological and religious themes. I provide concrete examples of displacement with psychedelic and Catholic mysticism, how it can be corrected, and how this would benefit dialogue. In the Conclusions, I outline persistent concerns and theological objections about some of the claims of psychedelic mysticism but hold onto the hope for further dialogue. My sustained attention is to the comparisons that are frequently made between the psychedelic and Catholic mystical experiences and whether these correlations are critically warranted. Full article
(This article belongs to the Section Religions and Theologies)
34 pages, 8310 KiB  
Review
Biomaterials for Regenerative Cranioplasty: Current State of Clinical Application and Future Challenges
by Lizhe He
J. Funct. Biomater. 2024, 15(4), 84; https://doi.org/10.3390/jfb15040084 (registering DOI) - 28 Mar 2024
Abstract
Acquired cranial defects are a prevalent condition in neurosurgery and call for cranioplasty, where the missing or defective cranium is replaced by an implant. Nevertheless, the biomaterials in current clinical applications are hardly exempt from long-term safety and comfort concerns. An appealing solution [...] Read more.
Acquired cranial defects are a prevalent condition in neurosurgery and call for cranioplasty, where the missing or defective cranium is replaced by an implant. Nevertheless, the biomaterials in current clinical applications are hardly exempt from long-term safety and comfort concerns. An appealing solution is regenerative cranioplasty, where biomaterials with/without cells and bioactive molecules are applied to induce the regeneration of the cranium and ultimately repair the cranial defects. This review examines the current state of research, development, and translational application of regenerative cranioplasty biomaterials and discusses the efforts required in future research. The first section briefly introduced the regenerative capacity of the cranium, including the spontaneous bone regeneration bioactivities and the presence of pluripotent skeletal stem cells in the cranial suture. Then, three major types of biomaterials for regenerative cranioplasty, namely the calcium phosphate/titanium (CaP/Ti) composites, mineralised collagen, and 3D-printed polycaprolactone (PCL) composites, are reviewed for their composition, material properties, and findings from clinical trials. The third part discusses perspectives on future research and development of regenerative cranioplasty biomaterials, with a considerable portion based on issues identified in clinical trials. This review aims to facilitate the development of biomaterials that ultimately contribute to a safer and more effective healing of cranial defects. Full article
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17 pages, 3145 KiB  
Article
Bimetallic Pt-IrOx/g-C3N4 Photocatalysts for the Highly Efficient Overall Water Splitting under Visible Light
by Nikolay D. Sidorenko, Polina A. Topchiyan, Andrey A. Saraev, Evgeny Yu. Gerasimov, Angelina V. Zhurenok, Danila B. Vasilchenko and Ekaterina A. Kozlova
Catalysts 2024, 14(4), 225; https://doi.org/10.3390/catal14040225 (registering DOI) - 28 Mar 2024
Abstract
Two series of bimetallic photocatalysts (0.5% Pt/0.01–0.5% IrOx/g-C3N4 and 0.1% Pt/0.01–0.1% IrOx/g-C3N4) were synthesized by the thermolysis of melamine cyanurate and a successive deposition of platinum and iridium labile complexes (Me4 [...] Read more.
Two series of bimetallic photocatalysts (0.5% Pt/0.01–0.5% IrOx/g-C3N4 and 0.1% Pt/0.01–0.1% IrOx/g-C3N4) were synthesized by the thermolysis of melamine cyanurate and a successive deposition of platinum and iridium labile complexes (Me4N)2[Pt2(μ-OH)2(NO3)8] and fac-[Ir(H2O)3(NO2)3. The synthesized photocatalysts were studied by a set of physicochemical analysis techniques. Platinum exists in two states, with up to 60% in metallic form and the rest in the Pt2+ state, while iridium is primarily oxidized to the Ir3+ state, which was determined by X-ray photoelectron spectroscopy (XPS). The specific surface area (SBET), which is determined by low-temperature nitrogen adsorption, ranges from 80 to 100 m2 g−1 and the band gap energy (Eg) value is in the range of 2.75–2.80 eV as found by diffuse reflectance spectroscopy (DRS). The activity of the photocatalysts was tested in the photocatalytic production of hydrogen from ultrapure water under visible light (λ = 400 nm). It was found that the splitting of water occurs with the formation of the stochiometric amount of H2O2 as an oxidation product. Two photocatalysts 0.5% Pt/0.01% IrOx/g-C3N4 and 0.1% Pt/0.01% IrOx/g-C3N4 showed the highest activity at 100 μmol h−1 gcat−1, which is among the highest in H2 production published for such systems. Full article
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20 pages, 1680 KiB  
Article
Research on Blockchain Transaction Privacy Protection Methods Based on Deep Learning
by Jun Li, Chenyang Zhang, Jianyi Zhang and Yanhua Shao
Future Internet 2024, 16(4), 113; https://doi.org/10.3390/fi16040113 (registering DOI) - 28 Mar 2024
Abstract
To address the challenge of balancing privacy protection with regulatory oversight in blockchain transactions, we propose a regulatable privacy protection scheme for blockchain transactions. Our scheme utilizes probabilistic public-key encryption to obscure the true identities of blockchain transaction participants. By integrating commitment schemes [...] Read more.
To address the challenge of balancing privacy protection with regulatory oversight in blockchain transactions, we propose a regulatable privacy protection scheme for blockchain transactions. Our scheme utilizes probabilistic public-key encryption to obscure the true identities of blockchain transaction participants. By integrating commitment schemes and zero-knowledge proof techniques with deep learning graph neural network technology, it provides privacy protection and regulatory analysis of blockchain transaction data. This approach not only prevents the leakage of sensitive transaction information, but also achieves regulatory capabilities at both macro and micro levels, ensuring the verification of the legality of transactions. By adopting an identity-based encryption system, regulatory bodies can conduct personalized supervision of blockchain transactions without storing users’ actual identities and key data, significantly reducing storage computation and key management burdens. Our scheme is independent of any particular consensus mechanism and can be applied to current blockchain technologies. Simulation experiments and complexity analysis demonstrate the practicality of the scheme. Full article
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12 pages, 4164 KiB  
Case Report
Molecular Features of HHV8 Monoclonal Microlymphoma Associated with Kaposi Sarcoma and Multicentric Castleman Disease in an HIV-Negative Patient
by Evelina Rogges, Sabrina Pelliccia, Camilla Savio, Gianluca Lopez, Irene Della Starza, Giacinto La Verde and Arianna Di Napoli
Int. J. Mol. Sci. 2024, 25(7), 3775; https://doi.org/10.3390/ijms25073775 (registering DOI) - 28 Mar 2024
Abstract
Human herpesvirus 8 (HHV8)-associated diseases include Kaposi sarcoma (KS), multicentric Castleman disease (MCD), germinotropic lymphoproliferative disorder (GLPD), Kaposi sarcoma inflammatory cytokine syndrome (KICS), HHV8-positive diffuse large B-cell lymphoma (HHV8+ DLBCL), primary effusion lymphoma (PEL), and extra-cavitary PEL (ECPEL). We report the case of [...] Read more.
Human herpesvirus 8 (HHV8)-associated diseases include Kaposi sarcoma (KS), multicentric Castleman disease (MCD), germinotropic lymphoproliferative disorder (GLPD), Kaposi sarcoma inflammatory cytokine syndrome (KICS), HHV8-positive diffuse large B-cell lymphoma (HHV8+ DLBCL), primary effusion lymphoma (PEL), and extra-cavitary PEL (ECPEL). We report the case of a human immunodeficiency virus (HIV)-negative male treated for cutaneous KS, who developed generalized lymphadenopathy, hepatosplenomegaly, pleural and abdominal effusions, renal insufficiency, and pancytopenia. The excised lymph node showed features of concomitant involvement by micro-KS and MCD, with aggregates of HHV8+, Epstein Barr virus (EBV)-negative, IgM+, and lambda+ plasmablasts reminiscent of microlymphoma. Molecular investigations revealed a somatically hypermutated (SHM) monoclonal rearrangement of the immunoglobulin heavy chain (IGH), accounting for 4% of the B-cell population of the lymph node. Mutational analyses identified a pathogenic variant of KMT2D and variants of unknown significance in KMT2D, FOXO1, ARID1A, and KMT2A. The patient died shortly after surgery. The histological features (HHV8+, EBV−, IgM+, Lambda+, MCD+), integrated with the molecular findings (monoclonal IGH, SHM+, KMT2D mutated), supported the diagnosis of a monoclonal HHV8+ microlymphoma, with features intermediate between an incipient HHV8+ DLBCL and an EBV-negative ECPEL highlighting the challenges in the accurate classification of HHV8-driven lymphoid proliferations. Full article
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13 pages, 3111 KiB  
Article
Engineering a Microphysiological Model for Regenerative Endodontic Studies
by Diana Sanz-Serrano, Montse Mercade, Francesc Ventura and Cristina Sánchez-de-Diego
Biology 2024, 13(4), 221; https://doi.org/10.3390/biology13040221 (registering DOI) - 28 Mar 2024
Abstract
Dental pulp infections are common buccal diseases. When this happens, endodontic treatments are needed to disinfect and prepare the root canal for subsequent procedures. However, the lack of suitable in vitro models representing the anatomy of an immature root canal hinders research on [...] Read more.
Dental pulp infections are common buccal diseases. When this happens, endodontic treatments are needed to disinfect and prepare the root canal for subsequent procedures. However, the lack of suitable in vitro models representing the anatomy of an immature root canal hinders research on regenerative events crucial in endodontics, such as regenerative procedures. This study aimed to develop a 3D microphysiological system (MPS) to mimic an immature root canal and assess the cytotoxicity of various irrigating solutions on stem cells. Utilizing the Dental Stem Cells SV40 (DSCS) cell line derived from human apical papilla stem cells, we analyzed the effects of different irrigants, including etidronic acid. The results indicated that irrigating solutions diminished cell viability in 2D cultures and influenced cell adhesion within the microphysiological device. Notably, in our 3D studies in the MPS, 17% EDTA and 9% 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP) irrigating solutions demonstrated superior outcomes in terms of DSCS viability and adherence compared to the control. This study highlights the utility of the developed MPS for translational studies in root canal treatments and suggests comparable efficacy between 9% HEBP and 17% EDTA irrigating solutions, offering potential alternatives for clinical applications. Full article
(This article belongs to the Section Cell Biology)
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12 pages, 2960 KiB  
Article
Quantum Yield Enhancement of Carbon Quantum Dots Using Chemical-Free Precursors for Sensing Cr (VI) Ions
by Karthiga Anpalagan, Hong Yin, Ivan Cole, Tian Zhang and Daniel T. H. Lai
Inorganics 2024, 12(4), 96; https://doi.org/10.3390/inorganics12040096 (registering DOI) - 28 Mar 2024
Abstract
Quantum yield illustrates the efficiency that a fluorophore converts the excitation light into fluorescence emission. The quantum yield of carbon quantum dots (CQDs) can be altered via precursors, fabrication conditions, chemical doping, and surface modifications. In this study, CQDs were first fabricated from [...] Read more.
Quantum yield illustrates the efficiency that a fluorophore converts the excitation light into fluorescence emission. The quantum yield of carbon quantum dots (CQDs) can be altered via precursors, fabrication conditions, chemical doping, and surface modifications. In this study, CQDs were first fabricated from whole-meal bread using a chemical-free hydrothermal route, and a low quantum yield (0.81%) was obtained. The combination of whole-meal bread, soybean flour, and lemon juice generated CQDs with almost four folds of enhancement in quantum yield. Detailed characterization suggested that these CQDs were subjected to more complete hydrothermal reactions and had zwitterionic surfaces. The CQDs could selectively detect Cr (VI) ions with a limit of detection (LOD) of 8 ppm. This study shows that the enhancement of the quantum yield of CQDs does not need chemicals, and it is achievable with food precursors. Full article
(This article belongs to the Special Issue Synthesis and Application of Luminescent Materials)
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21 pages, 5785 KiB  
Article
The Impact of Ar or N2 Atmosphere on the Structure of Bi-Fe-Carbon Xerogel Based Composites as Electrode Material for Detection of Pb2+ and H2O2
by Carmen I. Fort, Mihai M. Rusu, Liviu C. Cotet, Adriana Vulpoi, Milica Todea, Monica Baia and Lucian Baia
Gels 2024, 10(4), 230; https://doi.org/10.3390/gels10040230 (registering DOI) - 28 Mar 2024
Abstract
In this study, bismuth- and iron-embedded carbon xerogels (XG) were obtained using a modified resorcinol formaldehyde sol–gel synthesis method followed by additional enrichment with iron content. Pyrolysis treatment was performed at elevated temperatures under Ar or N2 atmosphere to obtain nanocomposites with [...] Read more.
In this study, bismuth- and iron-embedded carbon xerogels (XG) were obtained using a modified resorcinol formaldehyde sol–gel synthesis method followed by additional enrichment with iron content. Pyrolysis treatment was performed at elevated temperatures under Ar or N2 atmosphere to obtain nanocomposites with different reduction yields (XGAr or XGN). The interest was focused on investigating the extent to which changes in the pyrolysis atmosphere of these nanocomposites impact the structure, morphology, and electrical properties of the material and consequently affect the electroanalytical performance. The structural and morphological particularities derived from X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS) measurements revealed the formation of the nanocomposite phases, mostly metal/oxide components. The achieved performances for the two modified electrodes based on XG treated under Ar or N2 atmosphere clearly differ, as evidenced by the electroanalytical parameters determined from the detection of heavy metal cations (Pb2+) or the use of the square wave voltammetry (SWV) technique, biomarkers (H2O2), or amperometry. By correlating the differences obtained from electroanalytical measurements with those derived from morphological, structural, and surface data, a few utmost important aspects were identified. Pyrolysis under Ar atmosphere favors a significant increase in the α-Fe2O3 amount and H2O2 detection performance (sensitivity of 0.9 A/M and limit of detection of 0.17 μM) in comparison with pyrolysis under N2 (sensitivity of 0.5 A/M and limit of detection of 0.36 μM), while pyrolysis under N2 atmosphere leads to an increase in the metallic Bi amount and Pb2+ detection performance (sensitivity of 8.44 × 103 A/M and limit of detection of 33.05 pM) in comparison with pyrolysis under Ar (sensitivity of 6.47·103 A/M and limit of detection of 46.37 pM). Full article
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16 pages, 514 KiB  
Review
An Integrative Systematic Approach to Supporting Student Wellness: An Applied Case Example
by Kristy L. Brann, Mark Gallagher, Amity Noltemeyer and Kyle Bush
Educ. Sci. 2024, 14(4), 355; https://doi.org/10.3390/educsci14040355 (registering DOI) - 28 Mar 2024
Abstract
As schools work toward addressing the youth mental health crisis, Student Assistance Programs (SAPs) can serve as a service delivery model to proactively offer a continuum of support. A SAP involves education and building awareness, prevention, early identification, referral, intervention, and guided support [...] Read more.
As schools work toward addressing the youth mental health crisis, Student Assistance Programs (SAPs) can serve as a service delivery model to proactively offer a continuum of support. A SAP involves education and building awareness, prevention, early identification, referral, intervention, and guided support services. With the rising mental health need that was exacerbated by COVID-19, describing one district’s efforts can assist other schools in planning their own continuum of support within a SAP. This article provides a case example of one district’s efforts to create a system that integrates universal screening data and school and community support structures supporting students’ wellness. We describe the district’s continuum of support and early identification and intervention efforts, their systematic approach to integrating systems, and their teaming process. We will also report the percentages of students who are identified on wellness benchmarking and screening tools in addition to the percentage referred for additional support. We conclude by reviewing the implications for practice and future research. Full article
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23 pages, 4406 KiB  
Review
Recent Advances on Computational Modeling of Supported Single-Atom and Cluster Catalysts: Characterization, Catalyst–Support Interaction, and Active Site Heterogeneity
by Jiayi Xu, Colton Lund, Prajay Patel, Yu Lim Kim and Cong Liu
Catalysts 2024, 14(4), 224; https://doi.org/10.3390/catal14040224 (registering DOI) - 28 Mar 2024
Abstract
To satisfy the need for catalyst materials with high activity, selectivity, and stability for energy conversion, material design and discovery guided by theoretical insights are a necessity. In the past decades, the rise in theoretical investigations into the properties of catalyst materials, reaction [...] Read more.
To satisfy the need for catalyst materials with high activity, selectivity, and stability for energy conversion, material design and discovery guided by theoretical insights are a necessity. In the past decades, the rise in theoretical investigations into the properties of catalyst materials, reaction mechanisms, and catalyst design principles has shed light on the catalysis field. Quantitative structure–activity relationships have been developed through incorporating spectroscopic simulations, electronic structure calculations, and reaction mechanistic studies. In this review, we report the state-of-the-art computational approaches to catalyst materials characterization for supported single-atom and cluster catalysts utilizing spectroscopic simulations, i.e., XANES simulation, and material properties investigation via electronic-structure calculations. Furthermore, approaches regarding reaction mechanisms, focusing on active site heterogeneity, are also discussed. Full article
(This article belongs to the Special Issue Advanced Catalysis for Energy and Environmental Applications)
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15 pages, 593 KiB  
Article
Reduction in Emissions by Massive Solar Plant Integration in the US Power Grid
by Esteban A. Soto, Ebisa Wollega, Alexander Vizcarrondo Ortega, Andrea Hernandez-Guzman and Lisa Bosman
Energies 2024, 17(7), 1611; https://doi.org/10.3390/en17071611 (registering DOI) - 28 Mar 2024
Abstract
Fossil fuels, the predominant energy source in the United States, have been identified as major contributors to environmental pollution through the release of harmful emissions. As a countermeasure, there has been an increasing focus on the exploration and development of cleaner energy alternatives [...] Read more.
Fossil fuels, the predominant energy source in the United States, have been identified as major contributors to environmental pollution through the release of harmful emissions. As a countermeasure, there has been an increasing focus on the exploration and development of cleaner energy alternatives to alleviate the environmental degradation caused by fossil fuels and to satisfy the growing energy needs. This study conducted scenario analyses to evaluate the impact of integrating solar energy into specific US power grids on reducing carbon emissions. The analysis encompassed electrical systems within California, New England, New York, and the Southwest, utilizing datasets from the Energy Information Administration and National Renewable Energy Laboratory. The Energy Information Administration dataset includes information on net generation according to each source and carbon emissions according to fuel type, whereas the National Renewable Energy Laboratory dataset provides hourly projections for 6000 theoretical photovoltaic installations and detailed solar energy output data every five minutes over a year. Our findings indicated a notable decrease in carbon dioxide emissions following the introduction of solar power facilities. The most significant reductions were observed in the Southwest and California, attributed to solar plant integration. Conversely, New York and New England were identified as regions requiring additional policy measures and incentives to meet the emission reduction goals. Full article
(This article belongs to the Special Issue Solar Energy and Resource Utilization)
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16 pages, 10953 KiB  
Article
Detection and Comparison of Volatile Organic Compounds in Four Varieties of Hawthorn Using HS-GC-IMS
by Lijun Zhu, Feilin Ou, Yun Xiang, Bin Wang, Yingchao Mao, Lingfeng Zhu, Qun Zhang and Chang Lei
Separations 2024, 11(4), 100; https://doi.org/10.3390/separations11040100 (registering DOI) - 28 Mar 2024
Abstract
Hawthorn is a type of natural food with significant medicinal and nutritional properties; it has been listed in the “Both Food and Drug” list by the Chinese Ministry of Health Item List since 1997. However, hawthorn varieties have complex origins, and there are [...] Read more.
Hawthorn is a type of natural food with significant medicinal and nutritional properties; it has been listed in the “Both Food and Drug” list by the Chinese Ministry of Health Item List since 1997. However, hawthorn varieties have complex origins, and there are significant differences in the content, type, and medicinal efficacy of the chemically active ingredients in different varieties of hawthorn. This leads to the phenomenon of mixed varieties and substandard products being passed off as high-quality. In this work, by using headspace gas chromatography–ion mobility spectrometry (HS-GC-IMS), we identified and analyzed volatile organic compounds (VOCs) in four varieties of hawthorn, establishing their characteristic fingerprints. As a result, a total of 153 peaks were detected, and 139 VOCs were also identified. As shown by the fingerprint profiles, the different hawthorn samples contained different VOCs. Meanwhile, by using principal component analysis (PCA), Euclidean distance, and partial least-squares discriminant analysis (PLS-DA), the relationship between the VOCs found in the different varieties of hawthorn was revealed. This study developed a simple, fast, accurate, and sensitive method for identifying, tracking, and evaluating hawthorn varieties. Full article
(This article belongs to the Topic Advances in Analysis of Food and Beverages)
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15 pages, 14956 KiB  
Systematic Review
Reporting Quality and Risk of Bias Analysis of Published RCTs Assessing Anti-CGRP Monoclonal Antibodies in Migraine Prophylaxis: A Systematic Review
by Dimitrios Rikos, Michail Vikelis, Emmanouil V. Dermitzakis, Panagiotis Soldatos, Dimitrios Rallis, Jobst Rudolf, Anna P. Andreou and Andreas A. Argyriou
J. Clin. Med. 2024, 13(7), 1964; https://doi.org/10.3390/jcm13071964 (registering DOI) - 28 Mar 2024
Abstract
Objective: Phase II/III randomized clinical trials (RCTs) are vulnerable to many types of bias beyond randomization. Insights into the reporting quality of RCTs involving migraine patients treated with monoclonal antibodies targeting the calcitonin gene-related peptide system (anti-CGRP MAbs) are currently lacking. Our aim [...] Read more.
Objective: Phase II/III randomized clinical trials (RCTs) are vulnerable to many types of bias beyond randomization. Insights into the reporting quality of RCTs involving migraine patients treated with monoclonal antibodies targeting the calcitonin gene-related peptide system (anti-CGRP MAbs) are currently lacking. Our aim was to analyze the reporting quality of phase II/III RCTs involving migraine patients treated with anti-CGRP MAbs. Methods: A systematic search was performed on the PubMed and EMBASE databases, according to PRISMA guidelines, for relevant RCTs in either episodic or chronic migraine prevention. Additionally, an adapted version of the 2010 CONSORT statement checklist was utilized. The ROBvis online tool was used to document the risk of bias. Results: From the initially identified 179 articles, we finally found 31 RCTs that were eligible for evaluation. The average CONSORT compliance was 88.7% (69.7–100%), while 93.5% (N = 29) of the articles had a compliance greater than 75%. Twenty-eight CONSORT items were reported in more than 75% of the articles. The average compliance of the analyzed RCTs was 93.9% for Galcanezumab, 91.3% for Fremanezumab, followed by 85.4% for Erenumab and Eptinezumab studies. Implementation of the ROB2 tool showed some concerning “missing information” arising from the inadequate reporting. Specifically, 50% of the studies (N = 16) were categorized as having inadequate information regarding the randomization process. Conclusions: Adequate reporting quality was disclosed in the evaluated RCTs with anti-CGRP MAbs in migraine prevention. However, some methodological issues need to be highlighted to be addressed in future studies assessing the efficacy of new molecules targeting CGRP or other candidate pathways implicated in migraine pathophysiology. Full article
(This article belongs to the Section Clinical Neurology)
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